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KMID : 0359320160560010023
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Korean Journal of Veterinary Research
2016 Volume.56 No. 1 p.23 ~ p.28
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Genetic diversity of nucleocapsid genes of recent porcine epidemic diarrhea viruses isolated in Korea
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Kim Ki-Ju
Park Yoo-Kyung
Park Bo-Kyoung
Lam Truong-Wuang
Park So-Yeon
Kim Jae-Hoon
Hahn Tae-Wook
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Abstract
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Porcine epidemic diarrhea virus (PEDV), a porcine enteropathogenic coronavirus, causes lethal watery diarrhea in piglets, resulting in large economic losses because of high mortality. In November 2013, PEDV reemerged in Korea, and these outbreaks have since continuously occurred. In the present study, we determined the full-length nucleocapsid (N) gene sequences of three Korean PEDV field isolates collected in 2014?2015. Sequence and phylogenetic analysis of N genes revealed that recent prevalent Korean PEDV isolates were very closely related to the US PEDV isolates in 2013. Interestingly, the phylogenetic tree based on the nucleotide sequencing of the PEDV N gene was similar to the tree topology of the PEDV complete genomes. Therefore, our data provide a better understanding of the genetic diversity and contribute to the accurate diagnosis and development of vaccines against PEDV.
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KEYWORD
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Korean isolates, N gene, nucleocapsid, porcine epidemic diarrhea virus, phylogenetic analysis
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